Ausgewählte Publikationen

A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing

Balaji V, Müller L, Lorenz R, Kevei É, Zhang WH, Santiago U, Gebauer J, Llamas E, Vilchez D, Camacho CJ, Pokrzywa W, Hoppe T. Mol Cell. 2022 Sep 1;82(17):3239-3254.e11. doi: 10.1016/j.molcel.2022.08.003

Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity

Kokot T, Köhn M. J Cell Sci. 2022 Oct 1;135(19):jcs259618. doi: 10.1242/jcs.259618.

PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences

Kokot T, Hoermann B, Helm D, Chojnacki JE, Savitski MM, Köhn M. Methods Mol Biol. 2022;2499:43-64. doi: 10.1007/978-1-0716-2317-6_2

Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress

Lohanadan K, Molt S, Dierck F, van der Ven PFM, Frey N, Höhfeld J, Fürst DO. Exp Cell Res. 2021 Nov 15;408(2):112865. doi: 10.1016/j.yexcr.2021.112865

Maintaining proteostasis under mechanical stress.

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. EMBO Rep. 2021 Aug 4;22(8):e52507. doi: 10.15252/embr.202152507.

Overexpression of human BAG3P209L in mice causes restrictive cardiomyopathy

Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. Nat Commun. 2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7

Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores

Donkervoort S, Kutzner CE, Hu Y, Lornage X, Rendu J, Stojkovic T, Baets J, Neuhaus SB, Tanboon J, Maroofian R, Bolduc V, Mroczek M, Conijn S, Kuntz NL, Töpf A, Monges S, Lubieniecki F, McCarty RM, Chao KR, Governali S, Böhm J, Boonyapisit K, Malfatti E, Sangruchi T, Horkayne-Szakaly I, Hedberg-Oldfors C, Efthymiou S, Noguchi S, Djeddi S, Iida A, di Rosa G, Fiorillo C, Salpietro V, Darin N, Fauré J, Houlden H, Oldfors A, Nishino I, de Ridder W, Straub V, Pokrzywa W, Laporte J, Foley AR, Romero NB, Ottenheijm C, Hoppe T, Bönnemann CG. Am J Hum Genet. 2020 Dec 3;107(6):1078-1095. doi: 10.1016/j.ajhg.2020.11.002.

A molecular mechanism explaining albuminuria in kidney disease

Linus Butt, David Unnersjö-Jess, Martin Höhne, Aurelie Edwards, Julia Binz-Lotter, Dervla Reilly, Robert Hahnfeldt, Vera Ziegler, Katharina Fremter, Markus M. Rinschen, Martin Helmstädter, Lena K. Ebert, Hayo Castrop, Matthias J. Hackl, Gerd Walz, Paul T. Brinkkoetter, Max C. Liebau, Kálmán Tory, Peter F. Hoyer, Bodo B. Beck, Hjalmar Brismar, Hans Blom, Bernhard Schermer & Thomas Benzing; Nature Metabolism volume 2, pages 461–474(2020)

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA. Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052.

Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C

Lena Reimann, Anja N. Schwäble, Anna L. Fricke, Wignand W. D. Mühlhäuser, Yvonne Leber, Keerthika Lohanadan, Martin G. Puchinger, Sascha Schäuble, Erik Faessler, Heike Wiese, Christa Reichenbach, Bettina Knapp, Christian D. Peikert, Friedel Drepper, Udo Hahn, Clemens Kreutz, Peter F. M. van der Ven, Gerald Radziwill, Kristina Djinović-Carugo, Dieter O. Fürst & Bettina Warscheid Communications Biology volume 3, Article number: 253 (2020)

Proteome Analysis of Isolated Podocytes Reveals Stress Responses in Glomerular Sclerosis

Sybille Koehler, Alexander Kuczkowski, Lucas Kuehne, Christian Jüngst, Martin Hoehne, Florian Grahammer, Sean Eddy, Matthias Kretzler, Bodo B. Beck, Jörg Höhfeld, Bernhard Schermer, Thomas Benzing, Paul T. Brinkkoetter and Markus M. Rinschen JASN March 2020, 31 (3) 544-559; DOI: https://doi.org/10.1681/ASN.2019030312

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

Kumsta C, Chang JT, Lee R, Tan EP, Yang Y, Loureiro R, Choy EH, Lim SHY, Saez I, Springhorn A, Hoppe T, Vilchez D, Hansen M. Nat Commun. 2019 Dec 11;10(1):5648. doi: 10.1038/s41467-019-13540-4.

Unbiased pattern analysis reveals highly diverse responses of cytoskeletal systems to cyclic straining

Springer R, Zielinski A, Pleschka C, Hoffmann B, Merkel R. PLoS One. 2019 Mar 13;14(3):e0210570. doi: 10.1371/journal.pone.0210570. eCollection 2019.

The podocyte protease web: uncovering the gatekeepers of glomerular disease.

Rinschen MM, Huesgen PF, Koch RE. Am J Physiol Renal Physiol. 2018 Dec 1;315(6):F1812-F1816. doi: 10.1152/ajprenal.00380.2018.

The Hippo network kinase STK38 contributes to protein homeostasis by inhibiting BAG3-mediated autophagy

Klimek C, Jahnke R, Wördehoff J, Kathage B, Stadel D, Behrends C, Hergovich A, Höhfeld J. Biochim Biophys Acta Mol Cell Res. 2019 Oct;1866(10):1556-1566. doi: 10.1016/j.bbamcr.2019.07.007.

HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C

Collier MP, Alderson TR, de Villiers CP, Nicholls D, Gastall HY, Allison TM, Degiacomi MT, Jiang H, Mlynek G, Fürst DO, van der Ven PFM, Djinovic-Carugo K, Baldwin AJ, Watkins H, Gehmlich K, Benesch JLP. Sci Adv. 2019 May 22;5(5):eaav8421. doi: 10.1126/sciadv.aav8421.

Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function

Unger A, Beckendorf L, Böhme P, Kley R, von Frieling-Salewsky M, Lochmüller H, Schröder R, Fürst DO, Vorgerd M, Linke WA. Acta Neuropathol Commun. 2017 Sep 15;5(1):72. doi: 10.1186/s40478-017-0474-0.

BAG3-mediated proteostasis at a glance.

Klimek C, Kathage B, Wördehoff J, Höhfeld J. BAG3-mediated proteostasis at a glance. J Cell Sci 2017; 130:2781-2788

N-Degradomic analysis reveals a proteolytic network processing the podocyte cytoskeleton.

Rinschen MM*, Hoppe AK, Grahammer F, Kann M, Völker LA, Schurek EM, Binz J, Höhne M, Malisic M, Demir F, Malisic M, Huber TB, Kurschat C, Kizhakkedathu JN, Schermer B, Huesgen PF*, Benzing T* (2017) N-Degradomic analysis reveals a proteolytic network processing the podocyte cytoskeleton. J Am Soc Nephrol 28:2867-2878. *joint corresponding authors

Myofibrillar Z-discs are a protein phosphorylation hot spot with PKCα modulating protein dynamics.

Reimann L, Wiese H, Leber Y, Schwäble AN, Fricke A, Rohland A, Knapp B, Peikert CD, Drepper F, van der Ven PFM, Radziwill G, Fürst DO, Warscheid B (2017) Myofibrillar Z-discs are a protein phosphorylation hot spot with PKCα modulating protein dynamics. Mol Cell Proteomics 16: 346–367.

Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier.

Ising C, Bharill P, Brinkkoetter S, Brähler S, Schroeter C, Koehler S, Hagmann H, Merkwirth C, Höhne M, Müller RU, Fabretti F, Schermer B, Bloch W, Kerjaschki D, Kurschat CE, Benzing T, Brinkkoetter PT (2016) Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier. Am J Pathol 186: 1128-1139.

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Ulbricht A, Eppler FJ, Tapia VE, Van Der Ven PFM, Hampe N, Hersch N, Vakeel P, Stadel D, Haas A, Saftig P, Behrends C, Fürst DO, Volkmer R, Hoffmann B, Kolanus W, Höhfeld J (2013) Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy. Curr Biol 23: 430-435.

Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.

Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, Fürst DO (2016) Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Hum Mol Genet 25: 2776-2788.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.

Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T*, Clausen T* (2013) The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Cell 152: 183-195. *joint corresponding authors

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle.

Ulbricht A, Gehlert S, Leciejewski B, Schiffer T, Bloch W, Höhfeld J (2015) Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle. Autophagy 11: 538-546.

Chaperone-assisted selective autophagy is essential for muscle maintenance.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr Biol 20: 143–148.